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Voltage-Gated Ion Channels as Drug Targets (Methods and Principles in Medicinal Chemistry)-[1]-[2006]-[pdf]-[David J. Triggle, Murali Gopalakrishnan, David Rampe, Wei Zheng, Raimund Mannhold, Hugo Kubinyi, Ger]

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书籍信息:
书名: Voltage-Gated Ion Channels as Drug Targets (Methods and Principles in Medicinal Chemistry)
语言: English
格式: pdf
大小: 4.9M
页数: 488
年份: 2006
作者: David J. Triggle, Murali Gopalakrishnan, David Rampe, Wei Zheng, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
版次: 1
出版社: Wiley-VCH

简介

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology.After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development.For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.


目录
Cover......Page 1
Voltage-Gated Ion Channels as Drug Targets......Page 2
Methods and Principles in Medicinal Chemistry......Page 3
Copyright......Page 5
Contents......Page 6
Preface......Page 12
1 Introduction – On Ion Channels......Page 14
2 The Voltage-gated Ion Channel Superfamily......Page 19
3 State-dependent Drug Interactions with Ion Channels......Page 31
4 Assay Technologies: Techniques Available for Quantifying Drug–Channel Interactions......Page 49
5.1 Overview of Voltage-gated Calcium Channels......Page 76
5.2 Drugs Active at T-type Ca2+ Channels......Page 95
5.3 L-type Calcium Channels......Page 111
5.4 N-type Calcium Channels......Page 133
6.1 Molecular, Biophysical and Functional Properties of Voltage-gated Sodium Channels......Page 161
6.2 Small Molecule Blockers of Voltage-gated Sodium Channels......Page 178
7.1 Potassium Channels: Overview of Molecular, Biophysical and Pharmacological Properties......Page 203
7.2 Kv1.3 Potassium Channel: Physiology, Pharmacology and Therapeutic Indications......Page 224
7.3 Drugs Active at Kv1.5 Potassium Channels [1]......Page 285
7.4 Medicinal Chemistry of Ca2+-activated K+ Channel Modulators......Page 320
7.5 Drugs Active at ATP-sensitive K+ Channels......Page 345
7.6 Compounds that Activate KCNQ(2–5) Family of Potassium Ion Channels......Page 365
8.1 Inherited Disorders of Ion Channels......Page 391
8.2 Structural and Ligand-based Models for HERG and their Application in Medicinal Chemistry......Page 438
8.3 Ion Channel Safety Issues in Drug Development......Page 454
Index......Page 476

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